Interventions for sexual dysfunction in people with chronic obstructive pulmonary disease (COPD)

Area of Science:

• Pulmonary Medicine
• Sexual Health
• Clinical Trials

Background:

• Chronic obstructive pulmonary disease (COPD) is associated with a higher risk of sexual dysfunction compared to age-matched individuals.
• Sexual health issues in COPD can stem from hormonal, physiological, psychological factors, or relationship changes due to the chronic condition.

Purpose of the Study:

• To evaluate the effectiveness of interventions aimed at improving sexual dysfunction in individuals with COPD.

Main Methods:

• Searched multiple databases (e.g., Cochrane, MEDLINE, EMBASE) and trials registers up to July 2015.
• Included randomized controlled trials (RCTs), cluster RCTs, and quasi-RCTs assessing pharmacological, mechanical, psychological, or educational interventions.
• Two authors independently reviewed studies, extracted data, and assessed risk of bias.

Main Results:

• Included two studies with 48 male participants (moderate to very severe COPD).
• Low-quality evidence suggests testosterone therapy may improve erectile function, but not overall sexual satisfaction.
• Insufficient data exists on adverse events of testosterone therapy or the effects of oxygen therapy on erectile dysfunction.

Conclusions:

• Current clinical trial evidence is insufficient to guide interventions for sexual dysfunction in COPD patients.
• Clinicians currently rely on studies of non-COPD populations and expert opinion.
• Further clinical trials are necessary to establish effective interventions for improving sexual function and satisfaction in people with COPD.