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Drug Development in Low- and Middle-Income Countries: Opportunity or Exploitation?

Rakesh Jalali1, Angelica Nogueira-Rodrigues2, Arunangshu Das3

  • 1Neuro-Oncology Cancer Management Team, Apollo Proton Cancer Centre, Taramani, Chennai, India.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting
|June 6, 2022
PubMed

Insights

Low- and middle-income countries (LMICs) need better representation in global cancer drug trials. Collaboration and resource empowerment are key to achieving equitable and affordable cancer care worldwide.

Area of Science:

  • Oncology
  • Global Health
  • Clinical Trials

Background:

  • Cancer drug development predominantly occurs in high-income countries.
  • Low- and middle-income countries (LMICs) have minimal representation in global cancer trials.
  • This leads to inequitable access to optimal and affordable cancer care in LMICs.

Purpose of the Study:

  • To highlight the need for increased LMIC participation in global anticancer drug development.
  • To advocate for collaborative efforts to improve cancer care accessibility in LMICs.
  • To propose strategies for equitable drug development and distribution.

Main Methods:

  • Analysis of current global clinical trial structures.
  • Review of challenges and opportunities for LMIC involvement.
  • Examination of factors contributing to disparities in cancer care.

Main Results:

  • LMICs face significant underrepresentation in cancer clinical trials.
  • Despite challenges, LMICs possess growing potential to contribute to drug development.
  • Collaborative efforts are essential to leverage LMIC opportunities.

Conclusions:

  • Global drug development trials must prioritize LMIC representation and pragmatic study designs.
  • Enhanced collaboration between LMIC and high-income country researchers is crucial.
  • Empowering local investigators with resources can help eliminate cancer care disparities.

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