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Updated: Sep 21, 2025

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Setting the Stage for the Next Great Vaccine Success Story
1University of Pittsburgh Medical Centergrid.412689.0, Pittsburgh, Pennsylvania, USA.
Abstract:
In this Commentary, the article by Rosenfeld et al. "Cross-Reactive Antibody Responses against Nonpoliovirus Enteroviruses" is put into context of the historic poliovirus epidemics and resultant vaccination success story as it compares to the current state of acute flaccid myelitis; the relationship to nonpoliovirus enteroviruses (EVs), in particular EV-D68 and EV-A71; and the potential for successful vaccination strategies. The discovery of cross-protective antibody neutralization among polio and nonpolio enteroviruses, specifically EV-D68, opens future questions about EV-D68 vaccination strategies, circulation patterns of nonpolio enteroviruses, and the interpretation of EV-D68 serostudies.
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