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High-sensitivity C-reactive protein as a better predictor of post-thrombolytic functional outcome in patients with

Tan Li1, Qiannan Yu1, Yiqing Wang1

  • 1Stroke Center, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

European Journal of Medical Research
|June 6, 2022
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) correlates with modified Rankin Scale (mRS) scores in ischemic stroke patients. Antiplatelet therapy modifies this association, impacting functional outcome prediction.

Area of Science:

  • Biomarkers in Neurology
  • Inflammation and Cardiovascular Disease
  • Stroke Prognostics

Background:

  • C-reactive protein (CRP) is a key inflammation biomarker for cardiovascular and cerebrovascular disease prognosis.
  • The precise mechanism linking inflammation to ischemic stroke outcomes remains unclear.

Purpose of the Study:

  • To investigate the association between high-sensitivity C-reactive protein (hsCRP) and modified Rankin Scale (mRS) in ischemic stroke patients.
  • To explore the modifying effect of antiplatelet therapy on this relationship.

Main Methods:

  • Therapy-stratified analyses were conducted to examine the association between hsCRP and mRS.
  • The interaction effect of antiplatelet therapy was assessed.
  • Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive performance for poor outcomes.

Main Results:

  • hsCRP showed a positive correlation with mRS across therapy groups.
  • Antiplatelet therapy significantly modified the hsCRP-mRS association (P for interaction = 0.0101).
  • ROC analysis demonstrated improved discrimination of poor outcomes with hsCRP, particularly in patients on antiplatelet therapy (AUC increased from 0.709-0.713 to 0.758-0.872).

Conclusions:

  • hsCRP is associated with clinical outcomes in ischemic stroke patients treated with IV rt-PA.
  • hsCRP may serve as a valuable predictor of functional outcomes post-thrombolysis, especially in patients with prior antiplatelet therapy.
Abstract

Keywords:
AntiplateletNIHSShsCRPmRSrt-PA

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