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Short Bowel Syndrome and Dysmotility.
1Associate Professor, Division of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 6621 Fannin, Suite 6104, Houston, TX 77030, USA.
Clinics in Perinatology
|June 6, 2022
Summary
Short bowel syndrome (SBS) has lower mortality but high morbidity due to gut dysmotility. Current diagnostic and treatment options for SBS dysmotility are limited, necessitating new therapies and stronger evidence.
Area of Science:
- Pediatric gastroenterology
- Surgical innovation
- Parenteral nutrition complications
Background:
- Short bowel syndrome (SBS) survival has improved, yet significant morbidities persist.
- Gut dysmotility in SBS causes feeding intolerance and reliance on parenteral nutrition.
- Complications include liver disease and bloodstream infections, impacting patient outcomes.
Purpose of the Study:
- To review the current understanding of dysmotility in SBS.
- To evaluate existing diagnostic and therapeutic strategies for SBS dysmotility.
- To identify gaps in evidence for current treatments.
Main Methods:
- Literature review of recent advances in SBS.
- Analysis of diagnostic tools for infant dysmotility.
- Evaluation of medical and surgical treatment options for SBS dysmotility.
Main Results:
- Improved understanding of SBS dysmotility pathogenesis.
- Limited diagnostic tools and therapies for dysmotility in infants.
- Scarce and weak evidence supporting current medical and surgical treatments.
Conclusions:
- Newer therapies are needed for SBS dysmotility.
- Robust evidence is required to support existing treatments.
- Further research is crucial to improve management of SBS-related dysmotility.
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