Related Experiment Video
Updated: Sep 21, 2025
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
16.0K
Kidney delayed graft function after combined kidney-solid organ transplantation: A review
Kurtis J Swanson1, Brenda Muth2, Fahad Aziz2
1Division of Nephrology & Hypertension, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA 55414.
Transplantation Reviews (Orlando, Fla.)
|June 6, 2022
Summary
Kidney delayed graft function (K-DGF) impacts combined kidney-solid organ transplants (CKSOT). This review details K-DGF rates and risk factors across CKSOT subtypes, highlighting areas for future research.
Area of Science:
- Nephrology
- Transplantation Surgery
- Immunology
Background:
- Kidney delayed graft function (K-DGF) is a frequent complication after kidney transplantation, linked to poorer patient outcomes.
- Combined kidney-solid organ transplantation (CKSOT) is increasingly utilized for patients with combined kidney and other organ failure.
- K-DGF in the context of CKSOT remains under-researched.
Purpose of the Study:
- To review and summarize existing literature on K-DGF within various combined kidney-solid organ transplantation scenarios.
- To provide an overview of K-DGF incidence and associated risk factors in CKSOT.
- To identify knowledge gaps and encourage further investigation into K-DGF prevention and management in CKSOT.
Main Methods:
- Systematic literature review of studies reporting on K-DGF in combined kidney-solid organ transplantation.
- Analysis of K-DGF incidence rates across different CKSOT subtypes, including simultaneous pancreas-kidney, heart-kidney, and liver-kidney transplants.
- Identification and categorization of risk factors associated with K-DGF in CKSOT.
Main Results:
- K-DGF incidence varies significantly among CKSOT subtypes, with rates ranging from 8% in simultaneous pancreas-kidney transplants to 49% in simultaneous liver-kidney transplants.
- Specific risk factors for K-DGF were identified, some of which are common across CKSOT types, while others are unique to particular transplant combinations.
- Sequential kidney after thoracic or abdominal transplantation also shows distinct K-DGF rates.
Conclusions:
- K-DGF presents a significant challenge in combined kidney-solid organ transplantation, with incidence rates varying by transplant type.
- Understanding and addressing specific risk factors, some of which are modifiable, is crucial for reducing K-DGF incidence.
- Further research is essential to develop effective strategies for the prevention and management of K-DGF in the complex field of CKSOT.
Related Concept Videos
01:28Kidney Transplant I: Introduction
65
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
65
01:26Kidney Transplant II: Surgical Procedure
78
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
78
01:16Kidney Transplant III: Nursing Management
88
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
88
01:24Tissue Transplantation
530
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
530
01:29Acute Kidney Injury III: Clinical Manifestations
108
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
108