[Drug-induced extrapyramidal syndrome. Apropos of 22 cases]

We present extrapyramidal syndrome in 22 children (5 en 1984 and 17 during 1985) who received clebopride (15), metoclopramide (6) and haloperidol (1), almost all at the level of therapeutic doses, which fact seems to indicated a idiosyncratic factor. Symptoms occurred after 2.36 +/- 1.49 doses (mean+/- SD), and the most frequent was: dyskinetic movements (45.5%), oculogyric crisis (40.9%), uneasiness (40.9%) and hypertonic reaction (36.4%). The symptoms disappeared in all patients after drug administration was stopped and therapy with diphenhydramine or biperiden intravenously.