Chronic Nodular Prurigo: A Retrospective Study of 74 Cases

Area of Science:

• Dermatology
• Immunology
• Internal Medicine

Background:

• Chronic nodular prurigo (CNPG) is an underdiagnosed dermatological condition.
• CNPG is associated with various comorbidities, impacting patient management.
• Understanding CNPG pathogenesis has improved treatment options.

Purpose of the Study:

• To describe the clinical and sociodemographic characteristics of patients with CNPG.
• To report on the management and treatment outcomes for CNPG patients.
• To highlight the complexity and comorbidity profile of CNPG.

Main Methods:

• Single-center, observational, retrospective study.
• Inclusion of 74 patients diagnosed with CNPG between 2009 and 2021.
• Analysis of sociodemographic data, clinical characteristics, comorbidities, and treatment responses.

Main Results:

• The study included 74 patients, predominantly women (63.5%), with a mean age of 57.
• High prevalence of comorbidities: endocrine (54.1%), cardiovascular (44.4%), and psychiatric (36.5%).
• Elevated mean immunoglobulin E (IgE) levels (516 IU/mL) observed, with methotrexate being an effective treatment.

Conclusions:

• CNPG is a complex disease with significant comorbidity burden.
• A multidisciplinary approach is essential for managing CNPG, with dermatologists playing a central role.
• Conventional treatments may be insufficient, necessitating exploration of advanced therapies like methotrexate.