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Acral Papulovesicular Eruption in a Soldier Following Smallpox Vaccination
Brittany Lenz1, Eric Fillman1, Liesl Grenier1
1Drs. Lenz and Fillman are from the San Antonio Military Medical Center, Texas. Dr. Lenz is from the Department of Dermatology, and Dr. Fillman is from the Department of Dermatopathology. Dr. Grenier is from the Carl R. Darnall Army Medical Center Dermatology Clinic, Fort Hood, Texas.
Abstract:
Smallpox vaccination is associated with several potential cutaneous adverse reactions, ranging from benign self-limited hypersensitivity reactions to life-threatening eczema vaccinatum and progressive vaccinia. Acral papulovesicular eruption is a distinct presentation that has been described in US Military service members following vaccination with the second-generation smallpox vaccine (ACAM2000, Sanofi Pasteur Biologics Co). We describe a case of this unique cutaneous eruption and review previously described cutaneous adverse events associated with smallpox vaccination.
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