Assessment of the Kochak-Benet Equation for Hepatic Clearance for the Parallel-Tube Model: A Response to Jusko and Li

This commentary seeks to clarify the relationships between conservation of mass, spatial continuity, advective mass transport, and first-order drug metabolism in the liver. It also provides additional insight into the meaning of clearance thereby proving that the Pang-Rowland equation and its extensions are incorrect. The Kochak-Benet equation has been verified and is not a rearrangement of the Pang-Rowland equation.