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Shigella iron-binding proteins: An insight into molecular physiology, pathogenesis, and potential target vaccine

Che Muhammad Khairul Hisyam Bin Ismail1, Nor Raihan Mohammad Shabani2, Candy Chuah3

  • 1Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Vaccine
|June 6, 2022
PubMed

Insights

Shigella causes intestinal infections, and iron is crucial for its survival and virulence. Iron-binding proteins are key to Shigella

Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • Shigella is a significant cause of intestinal infections, particularly in vulnerable populations.
  • Shigellosis is endemic in Malaysia, with no current vaccine available.
  • Iron is essential for Shigella's survival, metabolism, and virulence within the host.

Purpose of the Study:

  • To review the physiological roles of iron-binding proteins in bacterial survival.
  • To explore the potential of iron-binding proteins in developing vaccines and therapeutics against Shigella.

Main Methods:

  • Literature review focusing on iron metabolism and virulence factors in Shigella.
  • Analysis of molecular regulation mechanisms for iron uptake and utilization.
  • Examination of existing research on iron-binding proteins in bacterial pathogenesis.

Main Results:

  • Iron availability significantly influences Shigella's adaptation and pathogenicity.
  • Iron-binding proteins are critical for acquiring and utilizing iron in limited environments.
  • Regulation of iron metabolism is a key factor in Shigella's virulence.

Conclusions:

  • Iron-binding proteins are vital for Shigella survival and pathogenicity.
  • Targeting iron-binding proteins presents a promising strategy for novel vaccine and therapeutic development against shigellosis.
Keywords:
Bacterial pathogenesisIron-binding proteinMultiple iron-uptake systemsShigella speciesSiderophoresVaccine development

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