Feasibility of a Generative Adversarial Network for Artifact Removal in Experimental Photoacoustic Imaging

Photoacoustic tomography (PAT) reconstruction is an expeditiously growing interest among biomedical researchers because of its possible transition from laboratory to clinical pre-eminence. Nonetheless, the PAT inverse problem is yet to achieve an optimal solution in rapid and precise reconstruction under practical constraints. Precisely, the sparse sampling problem and random noise are the main impediments to attaining accuracy but in support of rapid PAT reconstruction. The limitations are associated with acquiring undersampled artifacts that deteriorate the optimality of the reconstruction task. Therefore, the former achievements of fast image formation limit the modality for clinical settings. Delving into the problem, here we explore a deep learning-based generative adversarial network (GAN) to improve the image quality by denoising and removing these artifacts. The specially designed attributes and unique manner of optimizing the problem, such as incorporating the data set limitations and providing stable training performance, constitute the main motivation behind the employment of GAN. Moreover, exploitation of the U-net variant as a generator network offers robust performance in terms of quality and computational cost, which is further validated with the detailed quantitative and qualitative analysis. The quantitatively evaluated structured similarity indexing method = 0.980 ± 0.043 and peak signal-to-noise ratio = 31 ± 0.002 dB state that the proposed solution provides the high-resolution image at the output, even training with a low-quality data set.