Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure V: Medical Management

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Heart Failure VII: Nursing Interventions

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

Heart Failure Drugs: β-Blockers

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Empowering Heart Failure Patients: The Role, Importance, and Considerations of Active Patient Engagement in Improving Delivery of Guideline-Directed Medical Therapy.

Journal of patient experience·2025

Same author

Bivalirudin in Extracorporeal Membrane Oxygenation.

Journal of cardiovascular pharmacology·2024

Same author

Antimicrobial Pharmacokinetic Considerations in Extracorporeal Membrane Oxygenation.

Journal of clinical medicine·2024

Same author

Which SSRI is safest for patients with CVD and major depressive disorder?

JAAPA : official journal of the American Academy of Physician Assistants·2021

Same author

Evaluation of a Council Structure and Meeting Format for Pharmacy Student Government in the Co-Curriculum.

American journal of pharmaceutical education·2020

Same author

The Psychology of Following Instructions and Its Implications.

American journal of pharmaceutical education·2020

Search research articles

Related Experiment Video

Updated: Sep 21, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

The Perfect Storm: Barriers to Heart Failure Treatment Optimization.

Beth Towery Davidson¹, Sabrina Dunham²

¹Centennial Heart, LLC, TriStar Centennial Medical Center, 2400 Patterson Street, Nashville, TN 37203, USA.

Critical Care Nursing Clinics of North America

|June 6, 2022

Summary

Treatment gaps in heart failure care persist despite advances. Addressing provider, patient, and system factors is key to intensifying therapy and improving outcomes for heart failure patients.

Keywords:

Guideline-directed medical therapy Heart failure Treatment optimization clinical inertia

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

Related Experiment Videos

Last Updated: Sep 21, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

Area of Science:

Cardiology
Clinical Practice
Health Services Research

Background:

Heart failure (HF) remains a leading cause of morbidity and mortality despite therapeutic advancements.
Persistent treatment gaps exist, with suboptimal medication intensification contributing significantly to unmet clinical goals.

Purpose of the Study:

To examine the mechanisms and impact of factors contributing to treatment gaps in heart failure care.
To identify targeted initiatives for improving medication adherence and patient outcomes.

Main Methods:

Review of clinical practice patterns and treatment intensification strategies in heart failure management.
Analysis of provider, patient, and healthcare system barriers to evidence-based therapy.

Main Results:

Identified provider-related issues in initiating and titrating medications.
Highlighted patient-specific challenges in adherence and understanding treatment plans.
Examined systemic barriers within healthcare delivery affecting timely and effective care.

Conclusions:

Addressing the multifaceted barriers involving providers, patients, and healthcare systems is crucial.
Targeted interventions are needed to optimize heart failure treatment intensification and enhance patient outcomes.