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Updated: Sep 21, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
The Perfect Storm: Barriers to Heart Failure Treatment Optimization
Beth Towery Davidson1, Sabrina Dunham2
1Centennial Heart, LLC, TriStar Centennial Medical Center, 2400 Patterson Street, Nashville, TN 37203, USA.
Treatment gaps in heart failure care persist despite advances. Addressing provider, patient, and system factors is key to intensifying therapy and improving outcomes for heart failure patients.
Area of Science:
- Cardiology
- Clinical Practice
- Health Services Research
Background:
- Heart failure (HF) remains a leading cause of morbidity and mortality despite therapeutic advancements.
- Persistent treatment gaps exist, with suboptimal medication intensification contributing significantly to unmet clinical goals.
Purpose of the Study:
- To examine the mechanisms and impact of factors contributing to treatment gaps in heart failure care.
- To identify targeted initiatives for improving medication adherence and patient outcomes.
Main Methods:
- Review of clinical practice patterns and treatment intensification strategies in heart failure management.
- Analysis of provider, patient, and healthcare system barriers to evidence-based therapy.
Main Results:
- Identified provider-related issues in initiating and titrating medications.
- Highlighted patient-specific challenges in adherence and understanding treatment plans.
- Examined systemic barriers within healthcare delivery affecting timely and effective care.
Conclusions:
- Addressing the multifaceted barriers involving providers, patients, and healthcare systems is crucial.
- Targeted interventions are needed to optimize heart failure treatment intensification and enhance patient outcomes.
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