Related Experiment Video
Updated: Sep 21, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Reckless spreader or blameless victim? How vaccination status affects responses to COVID-19 patients
Marius C Claudy1, Suhas Vijayakumar1, Norah Campbell2
1University College Dublin, College of Business, Carysfort Avenue, Blackrock, Co. Dublin, Ireland.
Background:
Vaccination against Covid-19 has become an increasingly polarizing issue in western democracies. While much research has focused on social-psychological determinants of vaccine hesitancy, less is known about the attitudes and behaviors of the vaccinated populations towards those who are unvaccinated. Building on Weiner's attribution theory (2005, 1985, 1980), we predict that vaccination status determines the attribution of personal responsibility and blame in Covid-19 social dilemmas. This in turn explains people's affective and behavioral responses towards those who have fallen ill or infected others with COVID-19.
Approach:
Through two preregistered experiments (total N = 1200) we show that people attribute greater personal responsibility when unvaccinated (vs. vaccinated) people fall ill from, or infect others with COVID-19. This attribution of responsibility manifested in less sympathy towards unvaccinated COVID-19 patients, which was associated with a lower willingness to help patients and their families (Study 1). Likewise, higher perceived responsibility results in greater anger towards unvaccinated people who had (involuntarily) infected others with the virus, which was associated with a greater desire for punitive actions (Study 2).
Conclusion:
These findings suggest that unvaccinated people experience blame as well as negative attitudes and behaviors from the vaccinated population. This could in turn strengthen people's refusal to get vaccinated and increase polarization between vaccine supporters and vaccine critics.
Related Concept Videos
Vaccinations
Cross-reactivity
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

