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XIAP as a multifaceted molecule in Cellular Signaling

Mina Hanifeh1, Farangis Ataei2

  • 1Department of Biochemistry, Faculty of Biological Sciences, Trabiat Modares University, Tehran, Iran.

Apoptosis : an International Journal on Programmed Cell Death
|June 6, 2022
PubMed

Insights

X-linked inhibitor of apoptosis protein (XIAP) regulates cell death, inflammation, and proliferation. This review highlights XIAP's multifaceted roles in cellular signaling, including its impact on ROS production and copper homeostasis.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • X-linked inhibitor of apoptosis protein (XIAP) is a key member of the inhibitor of apoptosis protein family.
  • XIAP is known for its conserved inhibitory effect on caspase activity, regulating apoptosis.
  • Decades of research have elucidated XIAP's involvement in diverse cellular pathways.

Purpose of the Study:

  • To summarize key trends and roles of XIAP in cellular signaling.
  • To provide basic knowledge on XIAP's functions beyond apoptosis.
  • To focus on XIAP's regulation of ROS production and copper homeostasis.

Main Methods:

  • Literature review and synthesis of experimental findings.
  • Analysis of XIAP's involvement in various cellular processes.
  • Examination of XIAP's response to cellular stressors.

Main Results:

  • XIAP suppresses caspases and apoptosis, but also regulates inflammatory and mitogenic kinase signaling.
  • XIAP influences cell proliferation, invasion, metastasis, necroptosis, anoikis, autophagy, and neuronal differentiation.
  • XIAP plays a role in regulating intracellular reactive oxygen species (ROS) production and copper homeostasis.

Conclusions:

  • XIAP is a critical regulator of multiple cellular signaling pathways, extending beyond apoptosis.
  • XIAP's roles in ROS production, copper homeostasis, DNA damage response, and ER stress are significant.
  • Understanding XIAP's diverse functions is crucial for comprehending cellular fate and disease.
Keywords:
Cell deathER stressMultifunctionROS productionXIAP

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