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Published on: February 17, 2022
Teclistamab in Relapsed or Refractory Multiple Myeloma
Philippe Moreau1, Alfred L Garfall1, Niels W C J van de Donk1
1From the Hematology Clinic, University Hospital Hôtel-Dieu, Nantes (P.M.), Service d'Hématologie Clinique, Centre Hospitalier Lyon Sud, Pierre-Bénite (L.K.), and Service d'Hématologie et Thérapie Cellulaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire, Tours (L.B.) - all in France; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.L.G.), and Janssen Research and Development, Spring House (R.V., S.G., S.X.W.L., C.U., T.S., A.B.) - both in Pennsylvania; the Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam (N.W.C.J.D.); Karolinska University Hospital at Huddinge, Stockholm (H.N.); Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Investigación Sanitaria de Navarra, Pamplona (J.F.S.-M.), Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona (A.O.), Hospital Clínic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona (L.R.), University Hospital of Salamanca, Instituto de Investigación Biomédica de Salamanca, Centro del Investigación del Cáncer, CIBERONC, Salamanca (M.-V.M.), and Hematological Malignancies Clinical Research Unit, Hospital 12 de Octubre Universidad Complutense, Centro Nacional de Investigaciones Oncológicas, CIBERONC, Madrid (J.M.-L.) - all in Spain; Winship Cancer Institute, Emory University, Atlanta (A.K.N.); the University of California, San Francisco, San Francisco (T.M.), Stanford University School of Medicine, Stanford (S.S.), and City of Hope Comprehensive Cancer Center, Duarte (A.K.) - all in California; Mount Sinai School of Medicine (A.C.) and Memorial Sloan Kettering Cancer Center (S.Z.U.) - both in New York; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada (N.B.); Clinical Research Facility, National Institute for Health Research University College London Hospitals, NHS Foundation Trust, London (R.P.); the Department of Hematology, Oncology, and Immunology, University of Tübingen, Tübingen, Germany (B.B.); the University of Leuven, Leuven (M.D.), and Janssen Research and Development, Antwerp (Y.O., R.V.R.) - both in Belgium; Janssen Research and Development, Raritan, NJ (L.P., D.T., M.J., J.D.G., R.K.); and Levine Cancer Institute-Atrium Health, Charlotte, NC (S.Z.U.).
Teclistamab demonstrated significant efficacy in treating relapsed or refractory multiple myeloma, achieving deep and durable responses. Common side effects included cytopenias and infections, mostly low-grade, consistent with T-cell redirection therapy.
Area of Science:
- Oncology
- Immunotherapy
- Hematology
Background:
- Teclistamab is a bispecific antibody targeting CD3 on T cells and B-cell maturation antigen on myeloma cells.
- Previous studies indicated promising efficacy of teclistamab in relapsed or refractory multiple myeloma.
Purpose of the Study:
- To evaluate the efficacy and safety of teclistamab in patients with relapsed or refractory multiple myeloma.
- To assess response rates, duration of response, and progression-free survival in this patient population.
Main Methods:
- A phase 1-2 study enrolled patients with relapsed/refractory multiple myeloma after at least three prior therapies, including triple-class exposure.
- Patients received weekly subcutaneous teclistamab (1.5 mg/kg) following step-up doses.
- Primary endpoint was overall response rate (partial response or better).
Main Results:
- Overall response rate was 63.0% in 165 patients, with 39.4% achieving complete response or better.
- Median duration of response was 18.4 months, and median progression-free survival was 11.3 months.
- Common adverse events included cytokine release syndrome (72.1%), neutropenia (70.9%), anemia (52.1%), and infections (76.4%).
Conclusions:
- Teclistamab induces high rates of deep and durable responses in heavily pretreated multiple myeloma patients.
- Adverse events were primarily low-grade and consistent with T-cell redirection.
- The study supports teclistamab as a potential treatment option for relapsed/refractory multiple myeloma.
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