Malaria artemisinin resistance: an extracellular vesicles export hypothesis
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Updated: Sep 21, 2025

Evaluation of Extracellular Vesicle Function During Malaria Infection
Published on: February 14, 2018
Kwesi Z Tandoh1, Collins M Morang'a1, Michael Wilson2
1West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Abstract:
Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) - a drug used for managing malaria - threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.
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