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Updated: Sep 20, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral
Gabriel Dos Santos E Silva1, Joane Nátaly de Jesus Marques1, Emily Pacelli Moreira Linhares1
1Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, Brazil.
Abstract:
In recent years head-to-tail monoterpene geraniol has been widely explored as a potential anticancer agent. Natural analogs like alcohol nerol, aldehydes geranial, and neral have been investigated. We explored the synergism of these terpenes with clinically and non-clinically used compounds as potential candidates for treating different types of cancer. Promising activity for these compounds has also inspired new analog syntheses. The anticancer potential of these compounds is described in this review.
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