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Related Experiment Video

Updated: Sep 20, 2025

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

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Published on: March 10, 2015

Non-human primates in prion diseases.

Emmanuel E Comoy¹, Jacqueline Mikol², Jean-Philippe Deslys²

¹Service d'Etude des Prions et des Infections Atypiques, CEA, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. emmanuel.comoy@cea.fr.

Cell and Tissue Research

|June 6, 2022

Summary

This summary is machine-generated.

Nonhuman primates are crucial for understanding prion diseases, providing foundational knowledge on prion transmissibility and pathogenesis. These models remain vital for human health risk assessment and studying prion-like entities in neurodegenerative diseases.

Keywords:

Alzheimer’s disease Creutzfeldt-Jakob disease Nonhuman primate Prion Prion-like diseases Transmission

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Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain

Published on: October 3, 2012

Area of Science:

Neuroscience
Infectious Diseases
Prion Biology

Background:

Prion diseases are a group of fatal neurodegenerative disorders.
Nonhuman primates have historically played a critical role in prion disease research.
Understanding prion transmissibility, pathogenesis, and resistance is essential for public health.

Purpose of the Study:

To highlight the historical and ongoing importance of nonhuman primate models in prion disease research.
To emphasize the need for these models in current and future scientific endeavors.
To connect prion disease research with the broader field of prion-like entities in neurodegenerative diseases.

Main Methods:

Review of historical scientific literature on prion diseases and nonhuman primate models.
Analysis of the contribution of primate studies to fundamental knowledge of prions.
Discussion of the current relevance of these models for risk assessment and emerging research areas.

Main Results:

Nonhuman primate models have yielded fundamental insights into prion transmissibility, pathogenesis, and resistance.
These models continue to be indispensable for assessing risks to human health.
Primate studies provide a basis for investigating prion-like mechanisms in other neurodegenerative conditions.

Conclusions:

Nonhuman primate models are indispensable for advancing prion disease research.
Continued use of these models is critical for human health risk assessment.
Primate research is key to understanding the expanding field of prion-like entities, including Alzheimer's and Parkinson's diseases.