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Updated: Sep 20, 2025

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
Published on: March 10, 2015
Non-human primates in prion diseases
Emmanuel E Comoy1, Jacqueline Mikol2, Jean-Philippe Deslys2
1Service d'Etude des Prions et des Infections Atypiques, CEA, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. emmanuel.comoy@cea.fr.
Abstract:
The fascinating history of prion diseases is intimately linked to the use of nonhuman primates as experimental models, which brought so fundamental and founding information about transmissibility, pathogenesis, and resistance of prions. These models are still of crucial need for risk assessment of human health and may contribute to pave a new way towards the moving field of prion-like entities which now includes the main human neurodegenerative diseases (especially Alzheimer's and Parkinson's diseases).
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