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Coronin-1 levels in patients with tuberculosis.
Sanjeev Sinha1, Gaurav Gupta1, Sagnik Biswas2
1Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
The Indian Journal of Medical Research
|June 6, 2022
Summary
Tuberculosis (TB) patients show significantly higher levels of coronin 1a compared to healthy individuals. This suggests coronin 1a plays a role in TB pathophysiology and could be a potential drug target.
Area of Science:
- Immunology
- Infectious Diseases
- Molecular Biology
Background:
- Tuberculosis (TB) remains a global health burden despite medical advancements.
- Coronin is a leukocyte-specific protein involved in the host's defense against Mycobacterium.
- Coronin inhibits mycobacterial phagolysosome fusion by activating calcineurin.
Purpose of the Study:
- To investigate the role of coronin 1a in tuberculosis (TB) patients.
- To compare coronin 1a levels in TB patients versus healthy controls.
Main Methods:
- Prospective enrollment of 100 newly diagnosed TB patients and 100 healthy controls.
- Quantitative PCR (qPCR) was used to measure coronin 1a levels.
- Histopathological evidence was available for 47% of TB patients.
Main Results:
- Significantly elevated coronin 1a levels were found in TB patients (19.94±2.61) compared to healthy controls (16.09±1.91).
- The difference in coronin 1a levels was statistically significant (P<0.001).
Conclusions:
- Coronin 1a is implicated in the pathophysiology of tuberculosis.
- Targeting coronin may offer a novel therapeutic strategy for TB treatment.
- Further research is needed to validate coronin 1a as a diagnostic marker and drug target.
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