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[Antibiotic sensitivity of bacteria in the genus Proteus in relation to the source of isolation and specific
Abstract:
One hundred and ninety-one Proteus strains isolated from patients with various pathological processes were studied with respect to their sensitivity to 14 antibiotics. It was shown that their resistance depended on the isolation source and microbial species. Amikacin proved to be the most active agent. It was efficient against all the Proteus species, irrespective of the isolation source. Among the drugs efficient against P. mirabilis and P. vulgaris there were gentamicin, tobramycin and sisomicin sulphates.
Insights
This study analyzed 191 Proteus strains, finding antibiotic resistance varies by source and species. Amikacin demonstrated the highest effectiveness against all Proteus strains tested.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Proteus species are significant opportunistic pathogens in clinical settings.
- Understanding Proteus antimicrobial susceptibility is crucial for effective treatment.
- Antibiotic resistance patterns in Proteus can vary geographically and by patient population.
Purpose:
- To investigate the antibiotic sensitivity profiles of 191 Proteus strains.
- To identify the most effective antibiotics against Proteus species.
- To determine if resistance patterns differ based on isolation source and microbial species.
Summary:
- 191 Proteus strains from diverse pathological processes were tested against 14 antibiotics.
- Antibiotic resistance was found to be dependent on the isolation source and specific Proteus species.
- Amikacin exhibited broad-spectrum activity, proving effective against all tested Proteus species and sources.
- Gentamicin, tobramycin, and sisomicin sulphates were also effective against Proteus mirabilis and Proteus vulgaris.
Impact:
- Identifies Amikacin as a highly effective agent for Proteus infections.
- Provides valuable data for guiding empirical antibiotic therapy for Proteus.
- Highlights the importance of species and source-specific susceptibility testing for Proteus.