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Population pharmacokinetics and dosing optimization of mezlocillin in neonates and young infants

Jing Zhou1,2, Li Jiang3, Zhi Ling Zhang3

  • 1Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.

The Journal of Antimicrobial Chemotherapy
|June 6, 2022
PubMed

Insights

This study established a population pharmacokinetic model for mezlocillin in neonates. The findings provide optimal dosing regimens to improve treatment effectiveness for neonatal infections.

Area of Science:

  • Pharmacokinetics
  • Neonatal Pharmacology
  • Infectious Diseases

Background:

  • Mezlocillin is crucial for treating neonatal infections.
  • Current dosing regimens lack standardization due to limited population pharmacokinetic data in neonates and young infants.

Purpose of the Study:

  • To characterize mezlocillin pharmacokinetics in neonates and young infants.
  • To develop an optimal mezlocillin dosing regimen using a population pharmacokinetic model.

Main Methods:

  • A prospective, open-label pharmacokinetic study involving 48 neonates and young infants.
  • Plasma drug concentrations measured by HPLC; population pharmacokinetic modeling performed using NONMEM.
  • Covariate analysis identified postmenstrual age, weight, and serum creatinine as significant factors.

Main Results:

  • A two-compartment model with first-order elimination described mezlocillin pharmacokinetics.
  • Current 50 mg/kg q12h dosing achieved therapeutic targets in 89.2% of patients against MIC of 4 mg/L.
  • A 20 mg/kg q8h regimen achieved targets in 74.3% of patients.

Conclusions:

  • A robust population pharmacokinetic model for mezlocillin in neonates and young infants was successfully developed.
  • The study provides evidence-based, optimized dosing recommendations for mezlocillin in neonatal infections.
Abstract

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