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Related Experiment Videos

Single-dose ceftriaxone for chancroid.

M I Bowmer, H Nsanze, L J D'Costa

    Antimicrobial Agents and Chemotherapy
    |January 1, 1987
    PubMed
    Summary
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    A single 250 mg dose of intramuscular ceftriaxone effectively treats chancroid in men. This study found high cure rates across different ceftriaxone dosages for genital ulcers caused by Haemophilus ducreyi.

    Area of Science:

    • Infectious Diseases
    • Bacteriology
    • Dermatology

    Background:

    • Chancroid is a sexually transmitted infection caused by Haemophilus ducreyi.
    • Genital ulcers are a primary symptom of chancroid, necessitating effective treatment.

    Purpose of the Study:

    • To evaluate the efficacy of different intramuscular ceftriaxone dosage regimens for treating chancroid in men.
    • To determine the optimal single-dose regimen for chancroid treatment.

    Main Methods:

    • Men with culture-positive Haemophilus ducreyi genital ulcers were enrolled.
    • Participants received intramuscular ceftriaxone in varying dose regimens.
    • Cure rates were assessed for each treatment group.

    Main Results:

    Related Experiment Videos

    • A 1 g dose of ceftriaxone resulted in a 98% cure rate (49/50 men).
    • A 0.5 g dose achieved a 97.7% cure rate (43/44 men).
    • A 0.25 g dose demonstrated a 97.4% cure rate (37/38 men).

    Conclusions:

    • Single intramuscular doses of ceftriaxone are highly effective for treating chancroid.
    • A 250 mg (0.25 g) dose of intramuscular ceftriaxone is a confirmed effective treatment for chancroid.