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Dissolving microneedles: Applications and growing therapeutic potential
Ziad Sartawi1, Caroline Blackshields1, Waleed Faisal1
1School of Pharmacy, University College Cork, Cork, Ireland.
Summary
Dissolving microneedles offer superior drug delivery compared to other types, boasting simple fabrication and excellent drug loading. This review highlights their potential across various therapeutic applications and future directions.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmaceutical Sciences
Background:
- Microneedles facilitate transdermal delivery by creating microchannels in the skin.
- Coated and hollow microneedles face challenges like poor drug loading and pore blockage.
Purpose of the Study:
- To review recent developments and trends in dissolving microneedle technology.
- To discuss the advantages, disadvantages, fabrication, and applications of dissolving microneedles.
Main Methods:
- Literature review of research and clinical trials on dissolving microneedles.
- Analysis of fabrication materials, methods, and therapeutic applications.
Main Results:
- Dissolving microneedles exhibit superior drug loading and simplified fabrication/disposal.
- Potential applications span cosmetics, vaccines, diagnostics, cancer, pain, diabetes, and skin disorders.
Conclusions:
- Dissolving microneedles represent a promising drug delivery system with broad therapeutic potential.
- Further development and commercialization are supported by current trends and clinical trials.
