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Tools for Identifying Potentially Inappropriate Prescriptions for Children and Their Applicability in Clinical

Siyu Li1,2,3,4, Liang Huang1,2,3, Zhe Chen1,2,3

  • 1Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in Pharmacology
|June 6, 2022
PubMed

Insights

Potentially inappropriate prescription screening tools for children are limited, with most lacking validation. Developing and validating national tools is crucial for improving pediatric drug safety and rational prescribing.

Area of Science:

  • Pharmacovigilance and Drug Safety
  • Pediatric Pharmacology
  • Health Services Research

Background:

  • Drug use safety in children is a significant global public health concern.
  • Potentially inappropriate prescription (PIP) screening tools aim to minimize adverse drug reactions and promote rational medication use in pediatric populations.

Approach:

  • A systematic literature search was conducted across six major databases (PubMed, Embase, Cochrane Library, CNKI, VIP, Wanfang Data).
  • Two independent reviewers selected eligible articles and extracted relevant data.
  • Evaluated were the disease/drug coverage and item consistency among identified pediatric PIP screening tools.

Key Points:

  • Five pediatric PIP screening tools were identified, primarily developed via Delphi expert consensus, focusing on respiratory, anti-infective, and gastrointestinal drugs.
  • Significant variability in item overlap was observed between tools (e.g., POPI and POPI Int: 82.0%, POPI UK and PIPc: 2.2%), with KIDs List showing no overlap.
  • Only the French POPI tool demonstrated comprehensive validation; most other tools lack robust validation studies for clinical applicability.

Conclusions:

  • The field of pediatric potentially inappropriate prescribing screening tools is underdeveloped, with a critical need for validated instruments.
  • Future research should focus on developing and validating national PIP screening tools for children, grounded in robust clinical evidence and country-specific contexts.

Keywords:
adolescentsadverse drug reactionchildreninappropriate prescriptionspotential prescribing omissionpotentially inappropriate medicationrational drug use

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