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Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations
José Diogo S Souza1, Maíra Fassoni-Ribeiro2, Rayssa Miranda Batista3
1Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Frontiers in Pharmacology
|June 6, 2022
Summary
Cannabidiol (CBD) use may cause skin rash in some individuals. Further research is needed to understand this potential adverse effect of CBD, prompting clinical awareness.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Cannabidiol (CBD), a non-psychotomimetic compound from the Cannabis plant, shows therapeutic potential for various conditions.
- Isolated CBD is generally considered safe and well-tolerated.
- Existing literature on CBD-induced rash is limited, often involving concomitant medication use.
Observation:
- Four women developed skin rashes during ongoing Cannabidiol (CBD) use.
- Extensive viral and serological testing ruled out other causes for the rashes.
- Skin biopsies were performed on three patients, and two tolerated re-exposure to the vehicle (MCT) without adverse reactions.
Findings:
- The case reports suggest a potential link between Cannabidiol (CBD) and the development of skin rashes.
- The absence of rash upon re-exposure to the vehicle indicates CBD as the likely causative agent.
Implications:
- Clinicians should be aware of the possibility of skin rash as an adverse effect of Cannabidiol (CBD) therapy.
- Further investigation into the dermatological side effects of CBD is warranted.
- This highlights the importance of thorough patient history and monitoring for adverse events during CBD treatment.
