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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Related Experiment Video

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Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
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Steroid Stewardship.

Sanjay Kalra1,2, Ashok Kumar3, Rakesh Sahay4

  • 1Department of Endocrinology, BRIDE Hospital, Karnal, Haryana, India.

Indian Journal of Endocrinology and Metabolism
|June 6, 2022
PubMed
Summary
This summary is machine-generated.

Steroid stewardship ensures rational glucocorticoid use by balancing benefits and risks. This systematic approach involves careful prescription and monitoring to minimize adverse events in patients requiring corticosteroid therapy.

Keywords:
AdrenalCOVID-19endocrine pharmacologyglucocorticosteroidsiatrogenic Cushing’spharmacotherapeuticspharmacovigilance

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Patient Safety

Background:

  • Glucocorticoids are essential therapies but carry significant risks.
  • Current prescription and monitoring practices necessitate improvement.

Purpose of the Study:

  • To define and advocate for steroid stewardship.
  • To emphasize the importance of rational glucocorticoid management.

Main Methods:

  • Systematic review of glucocorticoid prescribing and monitoring practices.
  • Development of a framework for steroid stewardship.

Main Results:

  • Steroid stewardship encompasses pre-prescription screening, rational prescription, and ongoing medical care.
  • Effective monitoring is crucial even after corticosteroid discontinuation.

Conclusions:

  • A collective responsibility for steroid stewardship is needed.
  • Optimizing glucocorticoid therapy requires minimizing adverse events through systematic management.