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Bronchiolar adenoma with unusual presentation: Two case reports.

Ying Du1, Zheng-Yan Wang1, Zheng Zheng1

  • 1Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People's Hospital), Liaocheng 252000, Shandong Province, China.

World Journal of Clinical Cases
|June 6, 2022
PubMed
Summary

This study examines two rare distal bronchiolar adenoma cases, highlighting diagnostic challenges and the potential role of HER2 gene mutations in prognosis. Further research is needed to clarify their classification and malignant potential.

Keywords:
Bronchiolar adenomaCase reportCellular atypiaCiliated muconodular papillary tumorHuman epidermal growth factor receptor-2 geneThoracic tumors

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Area of Science:

  • Pulmonary Pathology
  • Oncology
  • Genetics

Background:

  • Retrospective analysis of two unusual distal bronchiolar adenoma cases.
  • Review of clinicopathological, immunohistochemical, and genetic profiles.
  • Focus on diagnostic challenges and potential malignant transformation.

Observation:

  • Case 1: Mild cells, focal bilayer structures, negative for common mutations.
  • Case 2: Atypical cells, focal bilayer structures, identified HER2 gene mutation.
  • Immunohistochemistry for P63 and CK5/6 revealed varying bilayer structures.

Findings:

  • Distal bronchiolar adenoma presents with diverse morphology.
  • HER2 gene mutation identified in one case, suggesting potential prognostic significance.
  • Uncertainty exists regarding classification as benign, atypical, or precursor lesions.

Implications:

  • Need for further studies to determine the nature of atypical bilayer structures.
  • Clarification of diagnostic criteria for atypical bronchiolar adenoma.
  • Investigating HER2 mutation as a prognostic marker in these lesions.