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Ultrastructural observations in lichen nitidus.

M Fimiani, C Alessandrini, A Castelli

    Archives of Dermatological Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Lichen nitidus (LN) and lichen planus (LP) may be variants of the same disease. Ultrastructural analysis of LN lesions revealed similarities to LP, suggesting a potential link between these dermatoses.

    Area of Science:

    • Dermatology
    • Pathology
    • Cell Biology

    Background:

    • Lichen nitidus (LN) and lichen planus (LP) are debated as distinct diseases or variants.
    • Understanding their relationship requires detailed pathological examination.

    Purpose of the Study:

    • To investigate the ultrastructural similarities between Lichen nitidus and Lichen planus.
    • To provide further evidence on the relationship between LN and LP.

    Main Methods:

    • Ultrastructural examination of skin lesions from two Lichen nitidus patients.
    • Analysis of cellular and subcellular changes in epidermal and dermal layers.

    Main Results:

    • Absence or interruption of the basement membrane in central lesion areas.

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  • Necrosis of basal and lower spinosum cells, with cellular debris in the upper dermis.
  • Dense dermal infiltrate including macrophages, lymphocytes, and Sezary-like cells, with signs of immune cell cooperation.
  • Epidermal changes at the periphery included enlarged intercellular spaces and scattered mononuclear cells.

    • Conclusions:

    • The observed ultrastructural findings in Lichen nitidus lesions closely resemble those previously reported for Lichen planus.
    • These similarities support the hypothesis that Lichen nitidus and Lichen planus may represent variants of the same underlying dermatosis.