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Modern Concepts in Cardiovascular Disease: Inflamm-Aging

Yustina M Puspitasari1, Stefano Ministrini1,2, Lena Schwarz1

  • 1Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.

Frontiers in Cell and Developmental Biology
|June 6, 2022
PubMed

Insights

Aging increases cardiovascular disease risk due to chronic inflammation, known as inflamm-aging. Understanding inflamm-aging

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Immunology

Background:

  • Increased life expectancy leads to a growing elderly population. Cardiovascular diseases are a major health concern in aging individuals.
  • Aging is associated with chronic, low-grade inflammation termed 'inflamm-aging'.
  • Inflammation plays a critical role in the development of cardiovascular diseases.

Purpose of the Study:

  • To review the molecular mechanisms linking inflamm-aging to cardiovascular disease.
  • To explore potential therapeutic strategies targeting inflamm-aging for cardiovascular conditions.

Main Methods:

  • Literature review of studies on aging, inflammation, and cardiovascular disease.
  • Analysis of molecular pathways involved in inflamm-aging.
  • Evaluation of anti-inflammatory therapies for age-related cardiovascular diseases.

Main Results:

  • Inflamm-aging is a significant factor in the pathogenesis of age-related cardiovascular diseases.
  • Specific molecular pathways connect chronic inflammation to cardiovascular dysfunction.
  • Several anti-inflammatory approaches show promise for treating these conditions.

Conclusions:

  • Inflamm-aging is a key contributor to age-associated cardiovascular diseases.
  • Targeting inflamm-aging pathways offers a promising therapeutic avenue.
  • Further research into anti-inflammatory strategies is warranted for cardiovascular health in aging populations.

Keywords:
agingcardiovascular diseaseinflammaginginflammationsenescence

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