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Zieve Syndrome in a Patient With Hepatitis C
Asad A Haider1, Joshua K Salabei1, Mariam Hashmi1
1Internal Medicine, University of Central Florida College of Medicine, Graduate Medical Education/Hospital Corporation of America (HCA) Florida North Florida Hospital, Gainesville, USA.
Cureus
|June 6, 2022
Summary
Zieve syndrome, a rare condition causing hemolytic anemia, jaundice, and hyperlipidemia in alcoholic liver disease patients, was identified in a hepatitis C patient. Early recognition is crucial to avoid misdiagnosis and ensure proper management.
Area of Science:
- Hepatology
- Hematology
- Internal Medicine
Background:
- Zieve syndrome is a rare clinical triad associated with alcoholic liver disease.
- It is characterized by hemolytic anemia, jaundice, and transient hyperlipidemia.
- This syndrome is often under-recognized, leading to diagnostic challenges.
Observation:
- A 30-year-old female with alcoholic liver disease and chronic hepatitis C presented with altered mental status and severe jaundice.
- Acute hemolytic anemia was diagnosed and attributed to Zieve syndrome after excluding other causes.
- The patient improved with alcohol abstinence and supportive care, including blood transfusions.
Findings:
- This case highlights a rare presentation of Zieve syndrome in a patient coinfected with hepatitis C virus.
- The study reviews the epidemiology, pathogenesis, diagnosis, and treatment of Zieve syndrome.
- A potential role for chronic hepatitis C in the pathophysiology of Zieve syndrome is hypothesized.
Implications:
- Increased medical awareness of Zieve syndrome is necessary to improve diagnostic accuracy.
- Timely diagnosis and management can prevent unnecessary interventions and improve patient outcomes.
- Further research into the interplay between hepatitis C and Zieve syndrome may elucidate novel pathophysiological mechanisms.
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