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Are Diabetic Patients at Increased Risk for Biochemical Recurrence After Radical Prostatectomy?
Houssem Ben Hadj Alouane1, Mehdi Raboudi1, Jasser Maatougui1
1Department of Urology, Military Hospital of Tunis, Tunisia, TUN.
Cureus
|June 6, 2022
Summary
Diabetes mellitus (DM) is linked to increased biochemical recurrence (BCR) risk after radical prostatectomy (RP), contrary to its lower prostate cancer risk. This finding is crucial for predicting BCR in patients undergoing RP.
Area of Science:
- Urology
- Oncology
- Endocrinology
Background:
- Diabetes mellitus (DM) is associated with a reduced risk of prostate cancer.
- The impact of DM on biochemical recurrence (BCR) after radical prostatectomy (RP) remains unclear.
Purpose of the Study:
- To investigate the predictive value of diabetes mellitus for biochemical recurrence after radical prostatectomy.
Main Methods:
- Retrospective analysis of 117 patients who underwent open radical prostatectomy (1999-2021).
- Univariate and multivariate statistical analyses were employed to identify predictors of BCR.
Main Results:
- Univariate analysis identified DM, elevated PSA, positive DRE, more positive biopsy cores, unfavorable risk group, PNI, tumor volume, and positive surgical margins as associated with BCR.
- Multivariate analysis revealed DM (OR=2.788), number of positive cores (OR=4.124), and positive surgical margins (OR=3.876) as independent predictors of BCR.
Conclusions:
- Diabetes mellitus should be considered a risk factor for biochemical recurrence post-radical prostatectomy.
- Further large-scale research is necessary to confirm DM's role as a biochemical recurrence predictor.
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