[Cardiovascular and digestive effects of 2 mydriatics in the low-birth-weight newborn infant]

Related Experiment Video

Updated: Aug 11, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

H Walti, P Daoud, B Broussin

    Archives Francaises De Pediatrie
    |January 1, 1987
    PubMed

    We studied the pupillary cardiovascular and gastrointestinal effects of two parasympathetic blocker mydriatics. Thirty-four neonates were randomly assigned into 3 groups: A: Atropine sulfate 0.3%, B: Tropicamide 0.5%, C: placebo. Mydriasis was obtained in groups A and B (p less than 0.001). No hypertension was observed and only an increase in heart rate with atropine was significant (p less than 0.001). Gastrointestinal side-effects studied in 25 children revealed a disturbance in groups A and B as compared to placebo (p less than 0.01). Tropicamide is therefore a more useful drug in low birth weight infants due to the absence of cardiovascular and hypertensive side-effects. Those infants with gastrointestinal disease should be treated with caution due to the side-effects which may be encountered.

    More Related Videos

    Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System07:34

    Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

    Published on: May 5, 2018

    In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus11:59

    In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

    Published on: April 28, 2023

    Related Concept Videos

    Factors Affecting Drug Response: Overview01:21

    Factors Affecting Drug Response: Overview

    When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
    Direct-Acting Cholinergic Agonists: Pharmacological Actions00:59

    Direct-Acting Cholinergic Agonists: Pharmacological Actions

    Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
    Cholinergic Antagonists: Pharmacological Actions01:28

    Cholinergic Antagonists: Pharmacological Actions

    Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
    Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
    Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers01:27

    Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

    β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in bronchial smooth...
    Adrenergic Antagonists: ɑ and β-Receptor Blockers01:31

    Adrenergic Antagonists: ɑ and β-Receptor Blockers

    Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is clinically...
    Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

    Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

    Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...