Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

127
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
127
Behavior Therapy01:22

Behavior Therapy

117
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
117
Traumatic Memory01:20

Traumatic Memory

249
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
249

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving Motivation in Post-stroke Apathy with Repetitive Transcranial Magnetic Stimulation (IMPART): A Phase-I Pilot Trial.

medRxiv : the preprint server for health sciences·2026
Same author

Identity matters: Exploring the role of race-based index trauma and racial identity in trauma-related psychopathology.

Psychological trauma : theory, research, practice and policy·2026
Same author

Integration of Cognitive Processing Therapy for PTSD and cognitive-behavioral therapy for co-occurring alcohol use disorder: Design and methodology of a randomized controlled trial.

Contemporary clinical trials·2026
Same author

Participant-centered tolerability of transcutaneous auricular vagus nerve stimulation: insights from two crossover studies.

Bioelectronic medicine·2026
Same author

The Manifestation of Structural Oppression Through Racial Trauma: Implications for Substance Use Among Black Adults.

Journal of psychoactive drugs·2026
Same author

Prevention of PTSD: Training the Brain.

The American journal of psychiatry·2026

Related Experiment Video

Updated: Sep 20, 2025

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.1K

Enhancing Prolonged Exposure therapy for PTSD using physiological biomarker-driven technology.

Sudie E Back1,2, Ron Acierno2,3, Tanya C Saraiya1

  • 1Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Contemporary Clinical Trials Communications
|June 6, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a new technology for therapist-guided in vivo exposures (IVEs) in Prolonged Exposure (PE) therapy for PTSD. The system uses real-time physiological data to enhance treatment effectiveness for veterans.

Keywords:
CAPS-5, Clinician-Administered PTSD Scale for DSM-5DSM-5, Diagnostic and Statistical Manual of Mental Disorders, Fifth EditionFDA, U.S. Food and Drug AdministrationIRB, Institutional Review BoardMINI, Mini International Neuropsychiatric InterviewMUSC, Medical University of South CarolinaMilitaryPCL-5, PTSD Checklist for DSM-5PTSDPTSD, posttraumatic stress disorderPhysiologyPosttraumatic stress disorderRCT, randomized controlled trialTechnologyU.S., United StatesVA, U.S. Department of Veterans AffairsVeterans

More Related Videos

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.2K
Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

12.7K

Related Experiment Videos

Last Updated: Sep 20, 2025

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.1K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.2K
Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

12.7K

Area of Science:

  • Psychiatry and Behavioral Science
  • Biomedical Engineering
  • Clinical Psychology

Background:

  • Prolonged Exposure (PE) therapy is a leading evidence-based treatment for posttraumatic stress disorder (PTSD).
  • In vivo exposures (IVEs) are crucial for PE but lack objective monitoring due to reliance on self-report.
  • A technological gap exists in providing real-time, therapist-guided support during patient-led IVEs.

Purpose of the Study:

  • To develop and evaluate an innovative system for physiological, biomarker-driven, therapist-guided IVEs.
  • To assess the feasibility and acceptability of this new technology in a clinical setting.
  • To conduct a pilot randomized clinical trial to examine the preliminary efficacy of the system in reducing PTSD symptoms.

Main Methods:

  • Integration of physiological sensors (heart rate, skin conductance) and live audio/visual streaming into a clinician-guided system.
  • Feasibility and acceptability assessments of the system.
  • A pilot randomized clinical trial with 40 veterans diagnosed with PTSD.

Main Results:

  • The study aims to demonstrate the successful integration of technology for real-time IVE guidance.
  • Preliminary data will be collected on the feasibility and acceptability of the system among users.
  • The pilot RCT will provide initial evidence on the system's efficacy in reducing PTSD symptoms.

Conclusions:

  • This technology has the potential to revolutionize exposure therapy by enabling objective, therapist-guided IVEs.
  • The findings could advance the science of exposure therapy and improve treatment outcomes for PTSD.
  • This innovative system may enhance clinician support and patient engagement during exposure therapy.