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Updated: Sep 20, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
Published on: June 26, 2018
α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
Lennart Brodin1, Dragomir Milovanovic2, Silvio O Rizzoli3
1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Abstract:
The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.
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