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Association of MicroRNAs With Risk of Stroke: A Meta-Analysis

Yidong Deng1, Peijian Huang1, Fan Zhang1

  • 1Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.

Frontiers in Neurology
|June 6, 2022
PubMed
Abstract

Insights

Altered microRNA (miRNA) expression is linked to ischemic stroke. This meta-analysis confirms abnormal miRNA levels as a potential diagnostic biomarker for stroke, showing high accuracy.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Neurology

Background:

  • MicroRNAs (miRNAs) play a role in disease development, including ischemic stroke.
  • Altered miRNA expression is implicated in the pathophysiology of ischemic stroke.

Approach:

  • A meta-analysis was conducted on 6 studies investigating miRNA expression panels for ischemic stroke diagnosis.
  • The Bayesian framework was employed, with heterogeneity assessed using I-squared and Cochran's Q-statistic.
  • Publication bias was evaluated using Begg and Egger tests.

Key Points:

  • The pooled sensitivity for diagnosing ischemic stroke using altered miRNA expression was 0.92 (95% CI 0.80-0.97).
  • The pooled specificity was 0.83 (95% CI 0.71-0.90).
  • The area under the summary receiver operating characteristic (SROC) curve was 0.93 (95% CI 0.90-0.95), indicating strong diagnostic performance.

Conclusions:

  • A significant association exists between miRNA dysregulation and ischemic stroke occurrence.
  • Abnormal miRNA expression represents a promising potential biomarker for the diagnosis of ischemic stroke.
Keywords:
diagnostic odds ratioischemic strokemeta-analysismicroRNAsensitivity

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