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Unusual Histopathological Findings in Mechanically Removed Stroke Thrombi - A Multicenter Experience
Oskar Aspegren1,2, Senna Staessens3, Sarah Vandelanotte3
1Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
Frontiers in Neurology
|June 6, 2022
Summary
This study analyzed rare stroke thrombi, finding unusual components like extracellular DNA and calcifications. These rare thrombi correlate with patient factors and mechanical thrombectomy techniques, improving stroke understanding.
Area of Science:
- Neurology
- Pathology
- Interventional Cardiology
Background:
- Stroke thrombi histopathology is studied, but rare components (1-2%) remain poorly understood.
- Limited knowledge exists regarding the composition and clinical relevance of unusual stroke thrombi.
Purpose of the Study:
- To characterize the histopathology of unusual stroke thrombi in a real-world setting.
- To correlate these findings with clinical presentation, patient characteristics, and mechanical thrombectomy procedures.
Main Methods:
- Retrospective analysis of 1008 mechanically retrieved stroke thrombi from three hospitals.
- Histopathological examination of 15 thrombi with unusual components.
- Collection of clinical and procedural data.
Main Results:
- Identified thrombi with extracellular DNA (some calcified), cholesterol, adipocyte-like patterns, collagen, myxomatous tissue, and vascular wall components.
- Described two distinct calcification types with varying morphology and cellular components.
- Found associations between unusual thrombus subgroups and underlying cardiovascular disease, patient demographics, and thrombectomy techniques.
Conclusions:
- Stroke thrombi exhibit rare histological subgroups with distinct clinical and procedural correlations.
- Understanding these unusual components enhances knowledge of stroke pathophysiology.
- Findings may influence interventional procedures and patient management strategies.
