[Morphofunctional changes in the heart, liver and skeletal muscles during temporary occlusion of the abdominal aorta]

Experimental abdominal aorta ligation at the bifurcation site was performed in anesthetized mongrel dogs (body mass 12-17 kg) under controlled respiration. Aortic ligation produced a significant effect on the physiological indices of cardiac function, ultrastructure of the myocardium, liver and musculus quadriceps femoris, as well as on the content of macroergic compounds in these organs. One-hour aortic occlusion caused mainly reversible dystrophic changes in the tissues studied; 2-8-hour aortic ligation led to much more severe changes in the skeletal musculature, liver, and heart, while reperfusion, as a rule, impaired the cardiac and hepatic status. The latter may be attributed to the release of neuromediators and intermediate metabolism products from the ischemic skeletal muscles.