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Updated: Sep 20, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
Published on: June 10, 2022
A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine
Fariba Saadati1, Silvia Cammarone1, Marco A Ciufolini1
1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Abstract:
This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.
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