Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patterns of auditory abnormality in multiple sclerosis.

J F Jerger, T A Oliver, R A Chmiel

    Audiology : Official Organ of the International Society of Audiology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Therapeutic attitudes towards multiple sclerosis in Central America and the Caribbean facing the SARS-CoV-2 pandemia].

    Neurologia·2020
    Same author

    Multiple sclerosis as a universal disease and the challenges to immigrants in high prevalence countries.

    European journal of neurology·2018
    Same author

    Some factors affecting the spondee threshold in normal-hearing subjects.

    Project report. USAF School of Aviation Medicine·2014
    Same author

    A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias.

    The New England journal of medicine·2013
    Same author

    Phase I/IIa trial of the mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced malignancies and sarcoma.

    Annals of oncology : official journal of the European Society for Medical Oncology·2012
    Same author

    Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

    Oral diseases·2010
    Same journal

    Apoptosis in the OC-k3 immortalized cell line treated with different agents.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Age-related histopathological changes of the stria vascularis: an experimental model.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Anatomical, metabolic and genetic aspects of age-related hearing loss in mice.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Effect of ageing on otoacoustic emissions and efferent suppression in humans.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Cochlear function and speech recognition in the elderly.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Determination and classification of the problems experienced by hearing-impaired elderly people.

    Audiology : official organ of the International Society of Audiology·2002
    See all related articles

    Multiple sclerosis (MS) frequently causes auditory problems. A combination of acoustic reflex (AR), speech audiometry (SA), and auditory brainstem response (ABR) tests identified 90% of auditory abnormalities in MS patients.

    Area of Science:

    • Neuroscience
    • Audiology
    • Clinical Neurology

    Background:

    • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
    • Auditory pathway dysfunction is a recognized but often underdiagnosed complication of MS.
    • Early detection of auditory abnormalities can aid in comprehensive patient management.

    Purpose of the Study:

    • To assess the prevalence and identification rates of auditory abnormalities in patients with definite multiple sclerosis.
    • To evaluate the diagnostic utility of a battery of auditory tests in MS.
    • To determine the most effective combination of tests for identifying auditory dysfunction in MS.

    Main Methods:

    • A cohort of 62 patients diagnosed with definite multiple sclerosis underwent a comprehensive auditory test battery.

    Related Experiment Videos

  • Tests included acoustic reflex (AR), auditory brainstem response (ABR), masking level difference (MLD), and speech audiometry (SA).
  • Data were analyzed to determine individual test identification rates and the efficacy of combined test results.
  • Main Results:

    • The acoustic reflex (AR) demonstrated the highest individual identification rate at 71%.
    • Speech audiometry (SA) followed with 55%, auditory brainstem response (ABR) at 52%, and masking level difference (MLD) at 45%.
    • A combination of AR, ABR, or SA achieved a 90% identification rate; AR, SA, or MLD achieved 87%.

    Conclusions:

    • Auditory abnormalities are highly prevalent in multiple sclerosis patients.
    • A combination of specific auditory tests, particularly AR, SA, and ABR, offers a high diagnostic yield for detecting auditory dysfunction in MS.
    • The auditory brainstem response (ABR) may not be essential when using a combination including AR, SA, and MLD for auditory abnormality detection in MS.