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The relationship between infarct volume and high sensitivity troponin I level in patients diagnosed with ischemic

Arif Aksu1, Akkan Avci2, Sadiye Yolcu1

  • 1Department of Emergency Medicine, Adana City Research and Training Hospital, Health Science University, 01060, Adana, Turkey.

Irish Journal of Medical Science
|June 6, 2022
PubMed

Insights

High-sensitivity troponin I (Hs-cTnI) may predict outcomes in acute ischemic stroke (AIS) patients. Elevated Hs-cTnI levels correlated with larger infarct volumes and higher mortality rates in this retrospective study.

Area of Science:

  • Neurology
  • Cardiology
  • Biomarker Research

Background:

  • Effective biomarkers for acute ischemic stroke (AIS) prognosis are needed.
  • Current diagnostic and prognostic tools for AIS require enhancement.

Purpose of the Study:

  • To evaluate the predictive value of high-sensitivity troponin I (Hs-cTnI) levels for AIS prognosis.
  • To determine if Hs-cTnI can identify patients with poorer outcomes.

Main Methods:

  • Retrospective observational study including 203 AIS patients (mean age 68.9).
  • Patients categorized into two groups based on Hs-cTnI levels (cut-off 8.5 mg/dL).
  • Infarct volume assessed via diffusion MRI; mortality data collected.

Main Results:

  • Higher Hs-cTnI levels (group 2) were significantly associated with larger infarct volumes.
  • Group 2 also exhibited a significantly higher mortality ratio (p=0.041).
  • Hs-cTnI demonstrated potential as a prognostic indicator in AIS.

Conclusions:

  • Hs-troponin I shows promise as an effective biomarker for predicting AIS prognosis.
  • Further multicenter prospective studies are recommended to validate these findings and strengthen evidence.
Abstract

Keywords:
Acute ischemic strokeEmergencyGKSHigh sensitive troponin IMortality

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