Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myocardial Fibroblast Activation in Ischemic and Nonischemic Cardiomyopathy.

JAMA cardiology·2026
Same author

Molecular Calcification Imaging and Ascending Aortic Disease in Patients With a Bicuspid Aortic Valve.

JAMA network open·2026
Same author

The loss of microRNA-26b promotes aortic calcification through the regulation of cell-specific target genes.

Cardiovascular research·2025
Same author

Roadmap analysis for coronary artery stenosis detection and percutaneous coronary intervention prediction in cardiac CT for transcatheter aortic valve replacement.

Journal of cardiovascular computed tomography·2025
Same author

Non-calcified Coronary Plaque Burden is Related to Epicardial Adipose Tissue and Peri-coronary Adipose Tissue Attenuation in Heart Failure With Preserved Ejection Fraction.

International journal of heart failure·2025
Same author

Priming with specific context improves large language model performance on nuclear cardiology board preparation test.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2025

Related Experiment Video

Updated: Sep 20, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.4K

Quantifying sodium [18F]fluoride uptake in abdominal aortic aneurysms.

Samuel Debono1, Jennifer Nash2, Alexander J Fletcher2

  • 1The University of Edinburgh Centre for Cardiovascular Science, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. samuel.debono@ed.ac.uk.

EJNMMI Research
|June 6, 2022
PubMed
Summary

A new method measuring aortic microcalcification activity using sodium [18F]fluoride positron emission tomography is faster and comparable to existing techniques. This optimized approach shows good repeatability for assessing abdominal aortic aneurysms.

Keywords:
AneurysmsImage analysisPositron emission tomographyRadiotracer

More Related Videos

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.4K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.6K

Related Experiment Videos

Last Updated: Sep 20, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.4K
Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
06:31

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

7.4K
18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

7.6K

Area of Science:

  • Nuclear medicine imaging
  • Cardiovascular research
  • Medical diagnostics

Background:

  • Aortic microcalcification activity measures sodium [18F]fluoride uptake in the thoracic aorta via PET.
  • This study aimed to adapt and evaluate this method for the infrarenal aorta in patients with abdominal aortic aneurysms.

Purpose of the Study:

  • To compare and modify the aortic microcalcification activity method for infrarenal aorta assessment.
  • To evaluate the agreement and repeatability of the modified method in patients with abdominal aortic aneurysms.

Main Methods:

  • Twenty-five patients with abdominal aortic aneurysms underwent sodium [18F]fluoride PET/CT scans.
  • Maximum and mean tissue-to-background ratios (TBR) and microcalcification activity were determined.
  • Thresholding and variable radius methods were applied to correct for signal spill-over and diameter changes.

Main Results:

  • The microcalcification activity method was significantly faster (14 vs. 40 min) than TBR.
  • Moderate-to-good agreement was found between TBR and microcalcification activity, improving with optimization techniques.
  • The optimized method demonstrated good intra-observer and inter-observer repeatability.

Conclusions:

  • Aortic microcalcification activity is a rapid and straightforward method for assessing sodium [18F]fluoride uptake.
  • The optimized method is comparable to established techniques and shows excellent repeatability.
  • This technique is suitable for evaluating abdominal aortic aneurysms.