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Anisomycin impairs long-term working memory in a delayed alternation task.

S J Mizumori, V Channon, M R Rosenzweig

    Behavioral and Neural Biology
    |January 1, 1987
    PubMed
    Summary
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    Protein synthesis inhibition by anisomycin disrupts working memory in rats. This study shows protein involvement is more critical for longer memory retention intervals than for the amount of information stored.

    Area of Science:

    • Neuroscience
    • Cognitive Science
    • Molecular Biology

    Background:

    • Working memory is crucial for cognitive tasks.
    • Protein synthesis inhibitors like anisomycin can impair memory.
    • Previous studies linked anisomycin to radial maze performance, but the role of information load versus retention time was unclear.

    Purpose of the Study:

    • To investigate the role of protein synthesis in working memory.
    • To differentiate between the effects of information amount and retention interval length on memory performance.
    • To assess the impact of anisomycin on a spatial delayed alternation task.

    Main Methods:

    • Rats were trained on a spatial delayed alternation task.
    • The protein synthesis inhibitor anisomycin was administered.

    Related Experiment Videos

  • Choice accuracy was measured to assess working memory performance.

    • Main Results:

    • Anisomycin impaired choice accuracy in the delayed alternation task.
    • The impairment was more pronounced with longer retention intervals.
    • Results suggest protein synthesis is more critical for temporal aspects of working memory.

    Conclusions:

    • Protein synthesis is essential for the temporal component of working memory.
    • The duration of the retention interval is a key factor in protein involvement.
    • This finding clarifies the role of protein synthesis in memory consolidation.