Simulation of multi-curve active catheterization for endovascular navigation to complex targets.

Area of Science:

• Biomedical Engineering
• Medical Devices
• Endovascular Therapies

Background:

• Endovascular therapies require precise navigation, but current simulations focus on aortic vasculature.
• Accessing complex targets like cerebral arteries remains challenging for endovascular navigation.

Purpose of the Study:

• To develop and characterize an active guidewire using Shape Memory Alloy (SMA) for improved endovascular navigation.
• To facilitate access to Supra-Aortic Trunks (SATs), specifically the left carotid artery.

Main Methods:

• Development of a test bench to measure guidewire and catheter velocities during navigation.
• Creation and validation of a numerical model for endovascular navigation in a complex phantom aorta.
• Experimental validation of the active guidewire's performance, including snapping and active curvatures.

Main Results:

• The numerical model accurately represented experimental phenomena like snapping and active curvatures.
• The active guidewire demonstrated effective navigation and interaction with simulated aortic structures.
• Successful engagement of the left carotid artery was achieved in three complex aorta phantoms by adapting the guidewire design.

Conclusions:

• The Shape Memory Alloy (SMA) active guidewire is a promising tool for complex endovascular navigation.
• This technology significantly improves the ability to access challenging anatomical targets, such as the left carotid artery.
• Further development and adaptation of guidewire design can enhance its clinical applicability in neurovascular interventions.