Related Experiment Video
Updated: Sep 20, 2025

Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Ruptured retinoblastoma: management in a rare case scenario
Aayesha Khanum1, Thirumalesh Mochi Basavaraj2, Gagan Dudeja1
1Narayana Nethralaya, Bangalore, India.
Abstract:
A preschool child presented with white reflex in left eye since 2 months. Examination under anaesthesia revealed left eye retinoblastoma group D as per international classification of retinoblastoma. In collaboration with medical oncologist, systemic chemotherapy was started. After two cycles of systemic chemotherapy, tumour ruptured into the vitreous cavity suspending the tumour cells in the vitreous jelly. After a combination of systemic and intravitreal chemotherapy with adjuvant transpupillary thermotherapy of the residual retinal tumour, retinoblastoma regressed completely with corresponding flat scar.

