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Related Concept Videos

Clinical Trials01:16

Clinical Trials

9.3K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Patient-centered Care01:13

Patient-centered Care

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Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
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Study Design in Statistics01:15

Study Design in Statistics

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A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
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Crossover Experiments01:16

Crossover Experiments

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Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
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Updated: Sep 20, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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Patient-centred clinical trial design.

Allison Tong1,2, Nicole Scholes-Robertson3,4, Carmel Hawley5,6

  • 1Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia. Allison.tong@sydney.edu.au.

Nature Reviews. Nephrology
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Summary
This summary is machine-generated.

Patient involvement in clinical trial design is crucial for kidney disease research. Engaging patients ensures trials address their needs, improving outcomes and research relevance.

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Area of Science:

  • Nephrology
  • Clinical Trials
  • Patient-Centered Research

Background:

  • Patient involvement in clinical trial design offers benefits like improved recruitment, retention, and intervention uptake.
  • Currently, patient involvement in nephrology trial design is limited, often neglecting patient-important research questions and outcomes.
  • This lack of patient input can reduce the relevance and value of trial evidence for clinical practice and health policy.

Purpose of the Study:

  • To highlight the importance of patient involvement in nephrology clinical trial design.
  • To advocate for increased patient engagement throughout the trial process.
  • To emphasize the potential for patient-centered trials to improve care and outcomes for individuals with kidney disease.

Main Methods:

  • Literature review and synthesis of current practices in clinical trial design.
  • Analysis of the impact of patient involvement on trial outcomes.
  • Identification of strategies to enhance patient engagement in nephrology research.

Main Results:

  • Patient-centered trials are more likely to address relevant research questions and patient-reported outcomes.
  • Increased patient involvement can enhance participant recruitment and retention rates.
  • Integrating patient perspectives ensures trial findings are valuable for decision-making.

Conclusions:

  • Actively involving patients in all stages of clinical trial design is essential for nephrology research.
  • Harnessing the patient voice leads to more relevant, reliable, and impactful trial evidence.
  • Patient-centered trials have the potential to drive transformative improvements in kidney disease care and patient outcomes.