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Updated: Sep 20, 2025
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Published on: November 28, 2018
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Relation between Selenium and Female Fertility: A Systematic Review
Luiz Gustavo Lima1, André Amaro Mamédio Dos Santos1, Tiago Daniel Gueiber1
1Department of Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil.
Summary
Selenium positively influences female fertility by increasing antioxidant levels and improving oocyte production. Supplementation may enhance reproductive efficiency in deficient women.
Area of Science:
- Reproductive Endocrinology
- Nutritional Science
- Biochemistry
Background:
- Selenium is an essential trace element with antioxidant properties.
- Its role in female reproductive health is an area of ongoing research.
- Micronutrient deficiencies can impact fertility outcomes.
Purpose of the Study:
- To systematically review the scientific literature on the influence of selenium on female fertility.
- To synthesize current evidence regarding selenium's impact on reproductive parameters.
Main Methods:
- Comprehensive literature search across multiple scientific databases (MEDLINE, Web of Science, Scopus, etc.) from 1996 to 2021.
- Systematic review methodology involving independent reviewer assessment and full-text evaluation.
- Data extraction included study characteristics, selenium concentrations, and fertility-related outcomes.
Main Results:
- Seven studies were included in the systematic review.
- A positive correlation was observed between serum selenium levels and antioxidant concentration in follicular fluid.
- Selenium was associated with reduced antithyroid antibodies, increased oocyte production, and a higher follicle count.
Conclusions:
- Selenium supplementation shows promise for improving reproductive efficiency in women with selenium deficiency.
- Adequate selenium levels may help prevent pregnancy complications.
- Further research is warranted to fully elucidate selenium's role in female reproductive health.
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