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Measuring Human Corneal Stromal Biomechanical Properties Using Tensile Testing Combined With Optical Coherence

Yi Song1, Di Wu2,3, Min Shen4

  • 1Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.

Frontiers in Bioengineering and Biotechnology
|June 7, 2022
PubMed
Summary
This summary is machine-generated.

This study measured human corneal stroma elasticity ex vivo using tensile testing and optical coherence tomography (OCT). Results show correlations between elastic modulus and in vivo biomechanical parameters, suggesting OCT

Keywords:
biomechanical propertiescorneadynamic response parametersmyopiaoptical coherence tomographytensile testing

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • Accurate assessment of corneal biomechanical properties is crucial for diagnosing and managing eye conditions.
  • Current in vivo methods provide indirect measures of corneal elasticity, necessitating validation with ex vivo data.
  • Optical coherence tomography (OCT) offers high-resolution imaging, potentially enhancing biomechanical assessments.

Purpose of the Study:

  • To determine the ex vivo elastic modulus of human corneal stroma via tensile testing combined with OCT imaging.
  • To correlate these ex vivo measurements with in vivo biomechanical parameters obtained using Scheimpflug technology (CorVis ST).
  • To explore the relationship between corneal elasticity and clinical characteristics, including refractive error.

Main Methods:

  • Human corneal stromal lenticules (n=24) from small incision lenticule extraction were prepared for uniaxial tensile testing.
  • Ex vivo elastic modulus (Low Strain Tangent Modulus - LSTM, High Strain Tangent Modulus - HSTM) was measured using tensile testing with OCT.
  • In vivo corneal biomechanical responses were assessed preoperatively using CorVis ST; Spearman's correlation analysis was employed.

Main Results:

  • Mean LSTM was 0.204 ± 0.189 MPa and mean HSTM was 5.114 ± 1.958 MPa.
  • Both LSTM and HSTM positively correlated with the stress-strain index (SSI).
  • LSTM correlated with A1 deflection parameters, while HSTM correlated with spherical equivalent; HSTM decreased with myopia.

Conclusions:

  • Corneal elastic modulus correlates with in vivo biomechanical parameters (SSI, A1 deflection) and refractive error (myopia).
  • The combination of tensile testing and OCT provides a promising method for assessing corneal biomechanical properties ex vivo.
  • These findings may enhance our understanding of corneal tissue elasticity and its clinical implications.