The effect of acute changes in glomerular filtration rate on common biochemical tests

To characterise the effect of acute kidney injury on the concentration of common biochemical analytes.

and methods: Pairs of serum or plasma samples from the same patients routinely submitted to the laboratory were subject to further analysis based on changes in serum creatinine within 72 h. Samples collected from patients on dialysis were excluded. Samples were measured for 28 biochemical analytes including electrolytes, liver function tests, iron studies, creatine kinase, amylase, lipase, parathyroid hormone, troponin T and troponin I, B-natriuretic peptide and NT pro B-natriuretic peptide.

148 sample pairs were included with 99 having a rise in serum creatinine >50%, 18 with a fall of >50% and 31 with smaller changes. Acute changes in renal function were associated with changes in the concentration of several analytes, with the changes of the greatest magnitude observed in urea, phosphate, urate, parathyroid hormone, troponin T, BNP and NT-ProBNP. The remaining analytes did not show significant changes with changes in renal function.

Acute changes in renal function are associated with significant changes in concentration of some serum/plasma biochemical analytes but not others. Expected changes in analyte concentration must be considered in the setting of acute kidney injury to avoid misinterpretation of blood test results.